Regulation of vascular endothelial growth factor-dependent retinal neovascularization by insulin-like growth factor-1 receptor |
| |
Authors: | Smith L E Shen W Perruzzi C Soker S Kinose F Xu X Robinson G Driver S Bischoff J Zhang B Schaeffer J M Senger D R |
| |
Institution: | Department of Ophthalmology, Harvard Medical School and Children's Hospital, 300 Longwood Avenue, Boston, Massachusetts 02115, USA. smith_lo@a1.tch.harvard.edu |
| |
Abstract: | Although insulin-like growth factor 1 (IGF-1) has been associated with retinopathy, proof of a direct relationship has been lacking. Here we show that an IGF-1 receptor antagonist suppresses retinal neovascularization in vivo, and infer that interactions between IGF-1 and the IGF-1 receptor are necessary for induction of maximal neovascularization by vascular endothelial growth factor (VEGF). IGF-1 receptor regulation of VEGF action is mediated at least in part through control of VEGF activation of p44/42 mitogen-activated protein kinase, establishing a hierarchical relationship between IGF-1 and VEGF receptors. These findings establish an essential role for IGF-1 in angiogenesis and demonstrate a new target for control of retinopathy. They also explain why diabetic retinopathy initially increases with the onset of insulin treatment. IGF-1 levels, low in untreated diabetes, rise with insulin therapy, permitting VEGF-induced retinopathy. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|