T-cell-mediated cytotoxicity toward platelets in chronic idiopathic thrombocytopenic purpura |
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| Authors: | Olsson Bob Andersson Per-Ola Jernås Margareta Jacobsson Stefan Carlsson Björn Carlsson Lena M S Wadenvik Hans |
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| Institution: | Research Center for Endocrinology and Metabolism, Sahlgrenska University Hospital, G?teborg University, SE-413 45 G?teborg, Sweden. |
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| Abstract: | Chronic idiopathic thrombocytopenic purpura (ITP) is a bleeding disorder that is characterized by increased platelet destruction and is believed to be autoantibody mediated. In this study, CD3+ T cells from ITP patients had increased expression of genes involved in cell-mediated cytotoxicity. In addition, cytotoxic cell-mediated lysis of autologous platelets was shown in active ITP. Our data suggest that T-cell-mediated cytotoxicity is an alternative mechanism for platelet destruction in ITP. |
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