The ets protein PEA3 suppresses HER-2/neu overexpression and inhibits tumorigenesis |
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| Authors: | Xing X Wang S C Xia W Zou Y Shao R Kwong K Y Yu Z Zhang S Miller S Huang L Hung M C |
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| Institution: | The University of Texas M.D. Anderson Cancer Center, Department of Cancer Biology, Section of Molecular Cell Biology, Houston, Texas 77030, USA. |
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| Abstract: | Because HER-2/neu overexpression is important in cancer development, we looked for a method of suppressing the cell transformation mediated by HER-2/neu overexpression. We have identified that the DNA-binding protein PEA3, which is encoded by a previously isolated gene of the ets family, specifically targeted a DNA sequence on the HER-2/neu promoter and downregulated the promoter activity. Expression of PEA3 resulted in preferential inhibition of cell growth and tumor development of HER-2/neu-overexpressing cancer cells. This is a new approach to targeting HER-2/neu overexpression and also provides a rationale to the design for repressors of diseases caused by overexpression of pathogenic genes. |
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