Broad HIV-1 neutralization mediated by CD4-binding site antibodies |
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| Authors: | Li Yuxing Migueles Stephen A Welcher Brent Svehla Krisha Phogat Adhuna Louder Mark K Wu Xueling Shaw George M Connors Mark Wyatt Richard T Mascola John R |
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| Institution: | Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA. |
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| Abstract: | We have identified several patient sera showing potent and broad HIV-1 neutralization. Using antibody adsorption and elution from selected gp120 variants, the neutralizing specificities of the two most broadly reactive sera were mapped to the primary receptor CD4-binding region of HIV-1 gp120. Novel antibodies to the CD4-binding site are elicited in some HIV-1-infected individuals, and new approaches to present this conserved region of gp120 to the immune system may result in improved vaccine immunogens. |
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