CD44 expression positively correlates with Foxp3 expression and suppressive function of CD4+ Treg cells |
| |
| Authors: | Tie Liu Lynn Soong Gang Liu Rolf König Ashok K Chopra |
| |
| Institution: | (1) Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA;(2) Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA |
| |
| Abstract: | Background CD4+CD25+ regulatory T (Treg) cells develop in the thymus and can suppress T cell proliferation, modulated by Foxp3 and cytokines; however, the relevance
of CD44 in Treg cell development is less clear. To address this issue, we analyzed Foxp3 expression in CD44+ Treg cells by using multiple parameters, measured the levels of the immunoregulatory cytokine interleukin (IL)-10 in various thymocyte
subsets, and determined the suppressor activity in different splenic Treg cell populations. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
