The cytokinin activities of 6-α-alkylbenzyloxypurines |
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Authors: | E J WILCOX C SELBY R L WAIN |
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Institution: | Department of Chemistry, University of Kent, Canterbury, Kent, CT2 7NH |
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Abstract: | The homologous series of 6-α-n-alkylbenzyloxypurines with alkyl groups (—(CH2)nCH3) from n = 0 to n = 11 have been prepared and examined in three tests for cytokinin activity. The parent benzyloxypurine was also included in the tests. Substituting methyl (n = 0) into the methylene group of 6-benzyloxypurine removed activity almost completely; thereafter, increasing the size of the alkyl group (n = 1–5) gave compounds which were active in all tests, the butyl (n = 3) and pentyl (n = 4) derivatives being more active than 6-benzyloxypurine itself. Activity then fell as the series was ascended; the higher homologues (n = 8–11) being completely inactive. The results are discussed in relation to steric and other considerations. |
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