Folded Structures in Protonated Reduced Dipeptides |
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Authors: | Vincent Grand Andr Aubry Virginie Dupont Andr Vicherat Michel Marraud |
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Institution: | Vincent Grand,André Aubry,Virginie Dupont,André Vicherat,Michel Marraud |
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Abstract: | Reduced dipeptides with the general formula RCO-Xaa- rXbb-N+HR′R′′ (rXbb, reduced analogue of residue Xbb: NH-Cα HR1 -Cr H2) are shown to adopt a folded conformation in solution and in the solid state. The protonated reduced amide bond is an active proton donor capable of interacting with a peptide carbonyl to give a strong hydrogen bond topologically equivalent to the i+2 or i+3? i interaction. The resulting conformation is similar to the γ- or β-turn structure found in peptides and proteins. |
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Keywords: | conformational analysis crystal structure folded structures pseudopeptides reduced peptides |
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