Life and death of female gametes during oogenesis and folliculogenesis |
| |
Authors: | Dmitri V Krysko Araceli Diez-Fraile Godelieve Criel Andrei A Svistunov Peter Vandenabeele Katharina D’Herde |
| |
Institution: | Dmitri V. Krysko, Araceli Diez-Fraile, Godelieve Criel, Andrei A. Svistunov, Peter Vandenabeele and Katharina D’Herde |
| |
Abstract: | The vertebrate ovary is an extremely dynamic organ in which excessive or defective follicles are rapidly and effectively eliminated
early in ontogeny and thereafter continuously throughout reproductive life. More than 99% of follicles disappear, primarily
due to apoptosis of granulosa cells, and only a minute fraction of the surviving follicles successfully complete the path
to ovulation. The balance between signals for cell death and survival determines the destiny of the follicles. An abnormally
high rate of cell death followed by atresia can negatively affect fertility and eventually lead irreversibly to premature
ovarian failure. In this review we provide a short overview of the role of programmed cell death in prenatal differentiation
of the primordial germ cells and in postnatal folliculogenesis. We also discuss the issue of neo-oogenesis. Next, we highlight
molecules involved in regulation of granulosa cell apoptosis. We further discuss the potential use of scores for apoptosis
in granulosa cells and characteristics of follicular fluid as prognostic markers for predicting the outcome of assisted reproduction.
Potential therapeutic strategies for combating premature ovarian failure are also addressed. |
| |
Keywords: | Granulosa cell Follicular fluid Follicular atresia Apoptosis Caspases Premature ovarian failure Autophagy Neo-oogenesis Gap junctions |
本文献已被 PubMed SpringerLink 等数据库收录! |