Role of <Emphasis Type="Italic">sie</Emphasis> Gene in Transient Depression of Macromolecular Synthesis in Phage P22-infected <Emphasis Type="Italic">Salmonella typhimurium</Emphasis> |
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Authors: | MAHARANI CHAKRAVORTY A K BHATTACHARYA |
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Institution: | 1.Department of Biochemistry and Biophysics,Institute of Medical Sciences, Banaras Hindu University,Varanasi |
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Abstract: | WE have shown that induction of the enzyme L-arabinose isomerase in Salmonella typhimurium ceases following infection with the bacteriophage P22 leading to lysis, whereas with infection leading to lysogeny there is a temporary inhibition of induction after which the synthesis of the enzyme begins again1. After infection, there is a transient depression of the overall rate of RNA and protein synthesis1. This phenomenon is similar to that observed in T-even phage and λ-infected E. coli2–5. Arguments for and against the involvement of phage genes2–12 in such phenomena have been put forward. We now present evidence to suggest that the sie gene of phage P22 is involved in the inhibition of host macromolecular synthesis. |
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