| Complete Genomic Sequence Analysis of a New SV40 Isolate |
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| 作者姓名： | Xue-mei ZHANG Yan-chun CHE Jing-jing WANG Long-ding LIU Ming-xue XIE Qi-han LI |
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| 作者单位： | Institute of Medical Biology，Chinese Academy of Medical Sciences and Peking Union Medical College，Kunming，Yunnan Province，650118，China |
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| 基金项目： | National Nature Science Founds(30570081) |
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| 摘 要： | The genome of a new SV40 strain (SV-IMB) isolated from a rhesus monkey was completely sequenced and compared with other isolates. The results showed that the whole genome contains 5246bp, and the average identity of SV-IMB was 98.1% as compared to other SV40 isolates. Its regulatory region is composed of a complete enhancer and a defective enhancer. Amino acid changes occurred to some extent in both the large T antigen (T-Ag) and VP1 region. The findings demonstrate that the SV-IMB is a new SV40 isolate.
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Complete Genomic Sequence Analysis of a New SV40 Isolate |
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| Xue-mei ZHANG,Yan-chun CHE,Jing-jing WANG,Long-ding LIU,Ming-xue XIE,Qi-han LI.Complete Genomic Sequence Analysis of a New SV40 Isolate[J].中国病毒学(英文版),2007,22(1):41-45. |
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| Authors: | Xue-mei ZHANG Yan-chun CHE Jing-jing WANG Long-ding LIU Ming-xue XIE Qi-han LI |
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| Institution: | Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, Yunnan Province, 650118, China |
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| Abstract: | The genome of a new SV40 strain (SV-IMB) isolated from a rhesus monkey was completely sequenced and compared with other isolates. The results showed that the whole genome contains 5246bp, and the average identity of SV-IMB was 98.1% as compared to other SV40 isolates. Its regulatory region is composed of a complete enhancer and a defective enhancer. Amino acid changes occurred to some extent in both the large T antigen (T-Ag) and VP1 region. The findings demonstrate that the SV-IMB is a new SV40 isolate. |
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| Keywords: | SV40 T-Ag Regulatory region |
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