| (s)-DHPA在小白鼠乳鼠体内对流行性出血热病毒抑制作用的初步观察 |
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| 引用本文： | 言晓,熊宏恩.(s)-DHPA在小白鼠乳鼠体内对流行性出血热病毒抑制作用的初步观察[J].Virologica Sinica,1989(3). |
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| 作者姓名： | 言晓 熊宏恩 |
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| 作者单位： | 湖南医科大学第一临床学院传染病学教研室 长沙 |
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| 摘 要： | 本文报道了(s)—9—(2,3-dihydroxypropyl)adenine(简称(s)-DHPA)对流行性出血热(EHF)病毒J_(10)株感染小白鼠乳鼠的影响。实验表明,两个(s)-DHPA治疗组感染乳鼠的发病率(44.44％、55.17％)和感染率(44.44％、55.17％)均较对照组的发病率(83.33％)和感染率(86.96％)明显降低。实验结果提示,(s)-DHPA具有一定的抑制EHF病毒在小白鼠乳鼠体内复制的作用,为临床开发治疗EHF的抗病毒新药提供了实验室依据。
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| 关 键 词： | (s)-DHPA EHF病毒 小白鼠乳鼠 |
Preliminary observation of the Inhibitory Effect of (s) DHPA on the Infection of EHFV in Suckling Mice |
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| Yan Xiao,Xiong Hong-en.Preliminary observation of the Inhibitory Effect of (s) DHPA on the Infection of EHFV in Suckling Mice[J].中国病毒学(英文版),1989(3). |
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| Authors: | Yan Xiao Xiong Hong-en |
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| Institution: | Yan Xiao,Xiong Hong-en Department of Infectious Disease,The First ffiliated Hospital,Hunan Med. University,Chongsha |
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| Abstract: | The inhibitory effect of (s)-9-(2, 3-dihydroxypropyl) adenine ((s)-DHPA)on infection of Epidemic Hemorrhagic Fever Virus (EHFV) J10 strain in su-ckling mice was observed. The experimental results showed that the morbidityrate (44.44 % and 55.17%) and infection rate (44.44% and 55.17%) of two(s)-DHPA treatment groups were markedly lower than that of the control group(83.33% and 86.96% respectively). Their differences were statistically signi-ficant. These results suggested that EHFV replication in suckling mice was ef-fectively inhibited by (s)-DHPA and our discovery would provide some referen-ce to the research of new antiviral drugs in the treatment of EHF and otherviral disease. |
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| Keywords: | (s)-DHPA EHFV Suckling mice |
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