Septins at the annulus of mammalian sperm |
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Authors: | Toure Aminata Rode Baptiste Hunnicutt Gary R Escalier Denise Gacon Gérard |
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Institution: | INSERM, U1016, Institut Cochin, Paris, France. aminata.toure@inserm.fr |
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Abstract: | The annulus is an electron-dense ring structure connecting the midpiece and the principal piece of the mammalian sperm flagellum. Proteins from the septin family have been shown to localize to the annulus. A septin complex is assembled early in spermiogenesis with the cochaperone DNAJB13 and, in mature sperm, associates with Testis Anion Transporter 1; SLC26A8 (Tat1), a transmembrane protein of the SLC26 family. Studies in mice have shown that the annulus acts as a barrier to protein diffusion and controls correct organization of the midpiece. Consistent with these findings, absence of the annulus is associated with flagellum differentiation defects and asthenozoospermia in humans. |
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