The swine histo compatibility system SLA: serological studies in the common Swiss and Danish swine breeds |
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| Authors: | Birte Kristensen Merete Philipsen S Lazary Christine Renard A L de Weck |
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| Institution: | Department of Animal Genetics, The Royal Veterinary and Agricultural University, Bülowsvej 13, DK-1870 Copenhagen V, Denmark;Institute for Animal Breeding, Division of Immuno genetics of the Veterinary School of the University of Berne, CH-3012 Berne, Switzerland;Laboratoire de Radio biologie Appliquée, CEA-INRA, Centre National de Recherches Zootechniques, 78350 Jouy-en-Josas, France;Institute for Clinical Immunology, Inselspital, CH-3010 Berne, Switzerland |
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| Abstract: | Alloantisera were produced in common Swiss and Danish swine breeds by immunization with leucocytes or skin-grafts. Out of the 126 antisera, 66 were chosen for further study based on titrations employing lymphocytes from unrelated pigs typed with French SLA antisera (Vaiman, Chardon & Renard, 1979). The 66 selected antisera and the French reagents defining 26 SLA specificities were used to type lymphocytes from 595 unrelated pigs of the common Swiss and Danish breeds. The reaction-patterns of the French, Swiss and Danish antisera were adequately correlated for the French SLA specificities Nos FJ 2, 3, 6, 7, 8, 9, 11, 14, 19, 20 and 24 and for the haplotypes FJ 15.1.18 and FJ 5.4. In addition, a cluster of correlated Danish and Swiss antisera characterized a new specificity, provisionally designated CPH 31. This specificity was frequent in the Danish Landrace pigs.
Using the reagents identified in this report, the segregation of SLA markers was studied. Back-cross families demonstrated segregation of 15 distinct SLA haplotypes of which 14 are common in French Landrace or Large White. Differences were found in haplotype frequencies in both the Swiss and the Danish Landrace and Large White breeds. |
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| Keywords: | swine histo compatibility system SLA serology SLA in Swiss and Danish swine breeds |
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