Midtrimester pregnancy interruption and the placental progesterone levels |
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Authors: | Fatma A Aleem MD PhD Harold Schulman MD |
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Institution: | Department of Gynecology and Obstetrics Albert Einstein College of Medicine Bronx, New York USA |
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Abstract: | Placental progesterone contents were studied in 10 patients therapeutically aborted at midtrimester by intraamniotic infusions of hypertonic saline, and from 14 patients (12–20 weeks) aborted by intraamniotic instillation of prostaglandin F2∝. The mean S.E. of the progesterone was 1.99± 0.07 ug/g. placental tissue in the first group, while with prostaglandin abortion the placental progesterone was 1.45± 0.09 ug/g. tissue, which is significantly lower than the results in the first group (P=0.001). The possible mechanism of action of prostaglandin as an effective abortifacient is discussed. |
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