Regulation and characterization of the Na+/H+ exchanger. |
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| Authors: | L Fliegel R Murtazina P Dibrov C Harris A Moor F A Fernandez-Rachubinski |
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| Institution: | Department of Biochemistry, University of Alberta, Edmonton, Canada. lfliegel@gpu.srv.ualberta.ca |
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| Abstract: | The Na+/H+ exchanger is a ubiquitous protein present in all mammalian cell types that functions to remove one intracellular H+ for one extracellular Na+. Several isoforms of the protein exist, which are referred to as NHE1 to NHE6 (for Na+/H+ exchanger one through six). The NHE1 protein was the first isoform cloned and studied in a variety of systems. This review summarizes recent papers on this protein, particularly those that have examined regulation of the protein and its expression and activity. |
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