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Reducing acetylated tau is neuroprotective in brain injury
Authors:Min-Kyoo Shin  Edwin Vázquez-Rosa  Yeojung Koh  Matasha Dhar  Kalyani Chaubey  Coral J Cintrón-Pérez  Sarah Barker  Emiko Miller  Kathryn Franke  Maria F Noterman  Divya Seth  Rachael S Allen  Cara T Motz  Sriganesh Ramachandra Rao  Lara A Skelton  Machelle T Pardue  Steven J Fliesler  Chao Wang  Andrew A Pieper
Institution:1. Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA;2. Department of Psychiatry, Case Western Reserve University, Cleveland, OH, USA;3. Geriatric Psychiatry, GRECC, Louis Stokes Cleveland VA Medical Center; Cleveland, OH, USA;4. Institute for Transformative Molecular Medicine, School of Medicine, Case Western Reserve University, Cleveland, OH, USA;5. Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA, USA;6. Department of Medicine, University Hospitals Cleveland Medical Center, Cleveland, OH, USA;7. Center for Visual and Neurocognitive Rehabilitation, Atlanta VA Healthcare System, Atlanta, GA, USA;8. Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, US;9. Departments of Ophthalmology and Biochemistry, and the Neuroscience Graduate Program, SUNY-University at Buffalo, Buffalo, NY, USA;10. Research Service, VA Western NY Healthcare System, Buffalo, NY, USA;11. Gladstone Institute of Neurological Disease, San Francisco, CA, USA;12. The Buck Institute, Novato, CA, USA;13. Helen and Robert Appel Alzheimer’s Disease Research Institute, Weill Cornell Medicine, New York, NY, USA;14. The Miami Project to Cure Paralysis, Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL, USA;15. Department of Neurosurgery, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA;16. Department of Neurology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, USA;17. Department of Biomedical Informatics, College of Medicine, Ohio State University, Columbus, OH, USA;18. Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA;19. Department of Biochemistry, UT Southwestern Medical Center, Dallas, TX, USA;20. MetroHealth Rehabilitation Institute, The MetroHealth System, Cleveland, OH;21. Department of Physical Medicine and Rehabilitation, Case Western Reserve University, School of Medicine, Cleveland, OH USA;22. Department of Psychiatry and Behavioral Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA;23. Mesulam Center for Cognitive Neurology and Alzheimer’s Disease, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA;24. Department of Pathology, Northwestern University, Chicago, IL, USA;25. Department of Pathology, Case Western Reserve University, School of Medicine, Cleveland, OH, USA;26. Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA;27. Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, OH, USA;28. Departments of Anesthesiology & Perioperative Medicine, University Hospitals Cleveland Medical Center, Cleveland, OH, USA;29. Weill Cornell Autism Research Program, Weill Cornell Medicine of Cornell University, New York, NY, USA;30. Department of Neuroscience, Case Western Reserve University, School of Medicine, Cleveland, OH, USA
Abstract:
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  • Keywords:neuroprotection  traumatic brain injury  Alzheimer’s disease  acetylation  tau  neurodegeneration  omigapil  congenital muscular dystrophy  salsalate  diflunisal  P7C3
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