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Genome-wide CRISPR Screens Reveal Host Factors Critical for SARS-CoV-2 Infection
Authors:Jin Wei  Mia Madel Alfajaro  Peter C DeWeirdt  Ruth E Hanna  William J Lu-Culligan  Wesley L Cai  Madison S Strine  Shang-Min Zhang  Vincent R Graziano  Cameron O Schmitz  Jennifer S Chen  Madeleine C Mankowski  Renata B Filler  Neal G Ravindra  Victor Gasque  Fernando J de Miguel  Ajinkya Patil  Huacui Chen  Craig B Wilen
Institution:1. Department of Laboratory Medicine, Yale School of Medicine, New Haven, CT 06520, USA;2. Department of Immunobiology, Yale School of Medicine, New Haven, CT 06520, USA;3. Genetic Perturbation Platform, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA;4. Department of Molecular Biophysics and Biochemistry, Yale School of Medicine, New Haven, CT 06520, USA;5. Department of Cell Biology, Yale University, New Haven, CT 06520, USA;6. Chemical Biology Institute, Yale University, West Haven, CT 06516, USA;7. Department of Pathology, Yale School of Medicine, New Haven, CT 06520, USA;8. Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520, USA;9. Department of Computer Science, Yale University, New Haven, CT 06520, USA;10. Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA;11. Yale Center for Molecular Discovery, Yale University, West Haven, CT 06516, USA;12. Department of Immunology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA;13. Department of Microbial Pathogenesis, Yale School of Medicine, New Haven, CT 06520, USA;14. Yale Cancer Center, Yale School of Medicine, New Haven, CT 06520, USA;15. Department of Pediatric Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02215, USA;16. Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA;17. Department of Medicine, Yale School of Medicine, New Haven, CT 06520, USA
Abstract:
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  • Keywords:SARS-CoV-2  COVID-19  CRISPR screen  HMGB1  SWI/SNF complex  MERS-CoV  Middle East Respiratory Syndrome  Severe Acute Respiratory Syndrome  Epigenetics
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