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B cell genomics behind cross-neutralization of SARS-CoV-2 variants and SARS-CoV
Authors:Johannes F Scheid  Christopher O Barnes  Basak Eraslan  Andrew Hudak  Jennifer R Keeffe  Lisa A Cosimi  Eric M Brown  Frauke Muecksch  Yiska Weisblum  Shuting Zhang  Toni Delorey  Ann E Woolley  Fadi Ghantous  Sung-Moo Park  Devan Phillips  Betsabeh Tusi  Kathryn E Huey-Tubman  Alexander A Cohen  Ramnik J Xavier
Institution:1. Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA;2. Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA;3. Center for Computational and Integrative Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA;4. Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA;5. Division of Infectious Diseases, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA;6. Laboratory of Molecular Virology, The Rockefeller University, New York, NY 10065, USA;7. Klarman Cell Observatory, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA;8. Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, 02215, USA;9. Department of Microbiology, NYU Grossman School of Medicine, New York, NY 10016, USA;10. Howard Hughes Medical Institute, Chevy Chase, MD, USA;11. Department of Molecular Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Abstract:
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  • Keywords:single B cell genomics  COVID-19  monoclonal antibodies  SARS-CoV cross-neutralization  memory B cells  cryo-electron microscopy  disordered CDRH3
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