Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability. |
| |
| Authors: | A H Peters D O'Carroll H Scherthan K Mechtler S Sauer C Sch?fer K Weipoltshammer M Pagani M Lachner A Kohlmaier S Opravil M Doyle M Sibilia T Jenuwein |
| |
| Institution: | Research Institute of Molecular Pathology (IMP), Vienna Biocenter, Dr. Bohrgasse 7, A-1030, Vienna, Austria. |
| |
| Abstract: | Histone H3 lysine 9 methylation has been proposed to provide a major "switch" for the functional organization of chromosomal subdomains. Here, we show that the murine Suv39h histone methyltransferases (HMTases) govern H3-K9 methylation at pericentric heterochromatin and induce a specialized histone methylation pattern that differs from the broad H3-K9 methylation present at other chromosomal regions. Suv39h-deficient mice display severely impaired viability and chromosomal instabilities that are associated with an increased tumor risk and perturbed chromosome interactions during male meiosis. These in vivo data assign a crucial role for pericentric H3-K9 methylation in protecting genome stability, and define the Suv39h HMTases as important epigenetic regulators for mammalian development. |
| |
| Keywords: | |
|
|
