In vitro traits of adenovirus-transformed cell lines and their relevance to tumorigenicity in nude mice |
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Authors: | Phillip H Gallimore James K McDougall Lan Bo Chen |
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Institution: | Department of Cancer Studies University of Birmingham The Medical School Birmingham B15 2TJ, England;Cold Spring Harbor Laboratory P.O. Box 100 Cold Spring Harbor, New York 11724 USA |
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Abstract: | Six independently isolated adenovirus 2-transformed rat cell lines and one adenovirus 5-transformed human cell line have been examined in vitro for serum growth requirements, saturation density, anchorage-independent growth, proteolytic enzyme activity and the presence of LETS glycoprotein and T antigen. This series of adenovirus-transformed cell lines exhibits an oncogenic spectrum ranging from being tumorigenic in immunocompetent rats through to nontumorigenic in adult nude mice. The relevance of the in vitro findings to growth potential in vivo is discussed. |
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