首页 | 本学科首页   官方微博 | 高级检索  
   检索      


ANKTM1, a TRP-like channel expressed in nociceptive neurons,is activated by cold temperatures
Authors:Story Gina M  Peier Andrea M  Reeve Alison J  Eid Samer R  Mosbacher Johannes  Hricik Todd R  Earley Taryn J  Hergarden Anne C  Andersson David A  Hwang Sun Wook  McIntyre Peter  Jegla Tim  Bevan Stuart  Patapoutian Ardem
Institution:Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
Abstract:Mammals detect temperature with specialized neurons in the peripheral nervous system. Four TRPV-class channels have been implicated in sensing heat, and one TRPM-class channel in sensing cold. The combined range of temperatures that activate these channels covers a majority of the relevant physiological spectrum sensed by most mammals, with a significant gap in the noxious cold range. Here, we describe the characterization of ANKTM1, a cold-activated channel with a lower activation temperature compared to the cold and menthol receptor, TRPM8. ANKTM1 is a distant family member of TRP channels with very little amino acid similarity to TRPM8. It is found in a subset of nociceptive sensory neurons where it is coexpressed with TRPV1/VR1 (the capsaicin/heat receptor) but not TRPM8. Consistent with the expression of ANKTM1, we identify noxious cold-sensitive sensory neurons that also respond to capsaicin but not to menthol.
Keywords:
本文献已被 PubMed 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号