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Characterizing Mutational Signatures in Human Cancer Cell Lines Reveals Episodic APOBEC Mutagenesis
Authors:Mia Petljak  Ludmil B Alexandrov  Jonathan S Brammeld  Stacey Price  David C Wedge  Sebastian Grossmann  Kevin J Dawson  Young Seok Ju  Francesco Iorio  Jose MC Tubio  Ching Chiek Koh  Ilias Georgakopoulos-Soares  Bernardo Rodríguez–Martín  Burçak Otlu  Sarah O’Meara  Adam P Butler  Andrew Menzies  Shriram G Bhosle  Michael R Stratton
Institution:1. Cancer, Ageing and Somatic Mutation, Wellcome Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, UK;2. Department of Cellular and Molecular Medicine and Department of Bioengineering, Moores Cancer Center, University of California, San Diego, La Jolla, CA 92093, USA;3. Oxford Big Data Institute, Old Road Campus, Oxford OX3 7LF, UK;4. Oxford NIHR Biomedical Research Centre, Oxford, OX4 2PG, UK;5. Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon 305-701, Republic of Korea;6. European Molecular Biology Laboratory - European Bioinformatics Institute, Hinxton, Cambridgeshire CB10 1SA, UK;7. Mobile Genomes and Disease, Molecular Medicine and Chronic Diseases Centre (CIMUS), Universidade de Santiago de Compostela, Santiago de Compostela 15706, Spain;8. Department of Zoology, Genetics and Physical Anthropology, Universidade de Santiago de Compostela, Santiago de Compostela 15706, Spain;9. The Biomedical Research Centre (CINBIO), Universidade de Vigo, Vigo 36310, Spain;10. Cytometry Core Facility, Wellcome Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, UK;11. Department of Medical Genetics, The Clinical School, University of Cambridge, Cambridge, CB2 0QQ, UK
Abstract:
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  • Keywords:mutational signatures  cancer cell lines  xenografts  APOBEC deaminases  episodic mutagenesis
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