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GSDMB is increased in IBD and regulates epithelial restitution/repair independent of pyroptosis
Institution:1. Department of Pathology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA;2. Departments of Physiology & Biophysics, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA;3. Institute for Computational Biology, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA;4. Department of Inflammation & Immunity, Learner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA;5. Departments of Cancer Biology and Colon & Rectal Surgery, Learner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA;6. MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom;7. Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA;8. Academic Department of Gastroenterology, Ethnikon & Kapodistriakon University of Athens, Laikon Hospital, Athens, Greece
Abstract:
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  • Keywords:gasdermins  gasdermin B  GSDMB  inflammatory bowel disease  intestinal epithelial cells  epithelial organoids  single-cell profiling  single-cell RNA-seq  methotrexate  Mtx  platelet-derived growth factor A  PDGFA  focal adhesion kinase  FAK  epithelial restitution and repair  resolution of inflammation
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