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Xist nucleates local protein gradients to propagate silencing across the X chromosome
Institution:1. Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA;2. Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA;3. Department of Computational Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA;4. Claremont McKenna College, Claremont, CA 91711, USA;5. European Molecular Biology Laboratory, Director’s Unit, Heidelberg 69117, Germany;6. Departments of Pharmacology & Chemistry and Biochemistry, University of California San Diego, San Diego, CA 92093, USA
Abstract:
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  • Keywords:heterochromatin  X chromosome inactivation  Xist RNA  RNA-binding proteins  biomolecular condensates  supramolecular complexes  chromatin organization  macromolecular dynamics  super-resolution microscopy  quantitative imaging
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