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Therapeutic Targeting of MLL Degradation Pathways in MLL-Rearranged Leukemia
Authors:Kaiwei Liang  Andrew G Volk  Jeffrey S Haug  Stacy A Marshall  Ashley R Woodfin  Elizabeth T Bartom  Joshua M Gilmore  Laurence Florens  Michael P Washburn  Kelly D Sullivan  Joaquin M Espinosa  Joseph Cannova  Jiwang Zhang  Edwin R Smith  John D Crispino  Ali Shilatifard
Institution:1. Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, 320 E. Superior St., Chicago, IL 60611, USA;2. Stowers Institute for Medical Research, 1000 E. 50th St., Kansas City, MO 64110, USA;3. Division of Hematology and Oncology, Northwestern University Feinberg School of Medicine, 303 E. Superior St., Chicago, IL 60611, USA;4. Department of Pathology and Laboratory Medicine, The University of Kansas Medical Center, Kansas City, KS 66150, USA;5. Linda Crnic Institute for Down Syndrome & Department of Pharmacology, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA;6. Oncology Institute, Loyola University Chicago, Maywood, IL 60153, USA;7. Department of Pathology, Loyola University Chicago, Maywood, IL 60153, USA;8. Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, 320 E. Superior St., Chicago, Il 60611, USA
Abstract:
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  • Keywords:mixed-lineage leukemia  MLL  wild-type MLL  MLL chimera  UBE2O  interleukin-1  IRAK4  IRAK1  super elongation complex  SEC
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