Identification of natural killer cell receptor clusters in the platypus genome reveals an expansion of C-type lectin genes |
| |
Authors: | Emily S W Wong Claire E Sanderson Janine E Deakin Camilla M Whittington Anthony T Papenfuss Katherine Belov |
| |
Institution: | (1) Faculty of Veterinary Science, University of Sydney, B19 RMC Gunn, Sydney, NSW, 2006, Australia;(2) Research School of Biological Sciences, Australian National University, Canberra, Australia;(3) Bioinformatics Division, The Walter and Eliza Hall Institute for Medical Research, Parkville, Australia |
| |
Abstract: | Natural killer (NK) cell receptors belong to two unrelated, but functionally analogous gene families: the immunoglobulin superfamily,
situated in the leukocyte receptor complex (LRC) and the C-type lectin superfamily, located in the natural killer complex
(NKC). Here, we describe the largest NK receptor gene expansion seen to date. We identified 213 putative C-type lectin NK
receptor homologs in the genome of the platypus. Many have arisen as the result of a lineage-specific expansion. Orthologs
of OLR1, CD69, KLRE, CLEC12B, and CLEC16p genes were also identified. The NKC is split into at least two regions of the genome: 34 genes map to chromosome 7, two map
to a small autosome, and the remainder are unanchored in the current genome assembly. No NK receptor genes from the LRC were
identified. The massive C-type lectin expansion and lack of Ig-domain-containing NK receptors represents the most extreme
polarization of NK receptors found to date. We have used this new data from platypus to trace the possible evolutionary history
of the NK receptor clusters.
Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorized users. |
| |
Keywords: | NKC Platypus Natural killer receptors Evolution Gene expansion Immune |
本文献已被 SpringerLink 等数据库收录! |
|