A new gene coding for an antigen recognized by autologous cytolytic T lymphocytes on a human renal carcinoma |
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| Authors: | Béatrice Gaugler Nathalie Brouwenstijn Valérie Vantomme Jean-Pierre Szikora Corry W Van der Spek Jean-Jacques Patard Thierry Boon Peter Schrier Benoît J Van den Eynde |
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| Institution: | (1) Ludwig Institute for Cancer Research, Brussels Branch, UCL 7459, 74 avenue Hippocrate, B1200 Brussels, Belgium;(2) Cellular Genetics Unit, Université Catholique de Louvain, B12GO Brussels, Belgium;(3) Dept of Clinical Oncology, Academic Hospital Leiden, Box 9600O, 2300 RC Leiden, The Netherlands |
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| Abstract: | Previous reports have described antigens that are recognized on human melanoma cells by autologous cytolytic T lymphocytes
(CTL). The genes coding for a number of these antigens have been identified. Here we report the cloning of a gene that codes
for an antigen recognized by autologous CTL on a human renal carcinoma cell line. This antigen is presented byHLA-B7 and is encoded by a new gene that we have namedRAGE1. No expression ofRAGE1 was found in normal tissues other than retina. RAGE1 expression was found in only one of 57 renal cell carcinoma samples,
and also in some sarcomas, infiltrating bladder carcinomas, and melanomas. This represents the first identification of an
antigen recognized by autologous CTL on a renal tumor. |
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