Nine major HLA class I supertypes account for the vast preponderance of HLA-A and -B polymorphism |
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Authors: | A Sette J Sidney |
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Institution: | (1) Epimmune Inc., 5820 Nancy Ridge Drive, Suite 100, San Diego, CA 92121, USA e-mail: jsidney@epimmune.com Tel.: +1-858-8602544, Fax: +1-858-8602600, US |
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Abstract: | Herein, we review the epitope approach to vaccine development, and discuss how knowledge of HLA supertypes might be used
as a tool in the development of such vaccines. After reviewing the main structural features of the A2-, A3-, B7-, and B44-
supertype alleles, and biological data demonstrating their immunological relevance, we analyze the frequency at which these
supertype alleles are expressed in various ethnicities and discuss the relevance of those observations to vaccine development.
Next, the existence of five new supertypes (A1, A24, B27, B58, and B62) is reported. As a result, it is possible to account
for the predominance of all known HLA class I with only nine main functional binding specificities. The practical implications
of this finding, as well as its relevance to understanding the functional implication of MHC polymorphism in humans, are discussed. |
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Keywords: | Vaccines Epitopes HLA Supertypes Polymorphism MHC |
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