Identification of two new alleles, IGHV3-23*04 and IGHJ6*04, and the complete sequence of the IGHV3-h pseudogene in the human immunoglobulin locus and their prevalences in Danish Caucasians |
| |
Authors: | Line Ohm-Laursen Stine Rosenkilde Larsen Torben Barington |
| |
Institution: | (1) Department of Clinical Immunology, Odense University Hospital, 5000 Odense C, Denmark |
| |
Abstract: | More than 100 variable (V), 27 diversity (D), and six joining (J) genes are encoded in the human heavy chain locus, and many
of these genes exists in different allelic forms. The number of genes and the allelic differences help to create diversity
in the immunoglobulin receptors, a key feature of the adaptive immune system. We here report the identification of two novel
and seemingly functional alleles of human heavy chain genes. The variable IGHV3-23*04 allele is found with an allele frequency of 0.21 amongst Danish Caucasians, whereas the novel joining IGHJ6*04 allele is rare (allele frequency 0.02). We also report the full sequence of IGHV3-h. The gene exists in two allelic forms but is only found in 58% of the Danish Caucasians studied. The methionine translation
initiation codon is mutated, ATG→AAG, and we therefore propose that the gene is a pseudogene incapable of being translated. |
| |
Keywords: | Immunoglobulin Alleles IGHV IGHJ Pseudogenes |
本文献已被 PubMed SpringerLink 等数据库收录! |
|