Kidney alloantigens determined by two regions of the rat major histocompatibility complex |
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| Authors: | Hugh ff S Davies Geoffrey W Butcher |
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| Institution: | (1) Department of Surgery, University of Cambridge, Agricultural Research Council, Institute of Animal Physiology, CB2 4AT Babraham, Cambridge, UK;(2) Institute of Animal Physiology, Agricultural Research Council, CB2 4AT Babraham, Cambridge, UK |
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| Abstract: | Recombination inH-1, the major histocompatibility complex (MHC) of the rat, has defined two regions,H-1A andH-1B, which determine antigens apparently homologous to the KJD and Ia antigens of the mouse, respectively. Alloantisera directed at these antigens have been absorbed with kidney homogenates. The results showed that cells in the kidney express serologically detectable MHC antigens determined by both theH-1A andH-1B region. Control absorptions indicated that to account for these results in terms of recirculating lymphocytes, two perfused kidneys would need to contain more than 60 percent of the recirculating lymphocyte pool. It appears likely, therefore, that H-1B antigens are expressed by cells resident in the kidney. |
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