Two different primate species express an identical functional MHC class I allele |
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Authors: | David T Evans Marian S Piekarczyk Luis Cadavid Virginia S Hinshaw D I Watkins |
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Institution: | (1) University of Wisconsin, Wisconsin Regional Primate Research Center, and Department of Pathology & Laboratory Medicine, 1220 Capitol Ct., Madison, WI 53715, USA, US;(2) University of Wisconsin, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI 53706, USA, US |
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Abstract: | The products of the highly polymorphic and variable major histocompatibility complex (MHC) class I loci play a crucial role
in host defenses against infectious disease. While similar alleles have been found in closely related species, sharing of
a functional MHC class I allele between two species has never been reported. Here we show that an identical functional MHC
class I molecule is present in two different primate species with an approximate divergence time of 0.7 million years. Lymphocytes
from the red-crested tamarin (Saguinus geoffroyi) expressed an MHC class I allele (Sage-G
*
01) that was identical in coding sequence to an MHC class I allele (Saoe-G
*
08) found in the cotton-top tamarin (Saguinus oedipus). Furthermore, influenza virus-specific cytotoxic T lymphocytes (CTLs) generated in the cotton-top tamarin killed lymphocytes
expressing the influenza virus nucleoprotein (NP) from the red-crested tamarin. Since the influenza virus NP epitope is bound
by Saoe-G*08 in the cotton-top tamarin, it is likely that this molecule is functional in both species. These data provide the first
evidence that functional MHC class I molecules can be maintained entirely intact in two separate species.
Received: 6 June 1997 / Revised: 21 July 1997 |
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Keywords: | MHC class I Cotton-top tamarin Influenza New World Primates Cytotoxic T lymphocytes |
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