B-Cell responses to male-specific antigen(s) in mice |
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| Authors: | Richard J T Hancock David W Dresser |
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| Institution: | (1) National Institute for Medical Research, NW7 1AA London, UK;(2) Present address: UK Transplant Service, S. W. Regional Transfusion Centre, BS10 5ND Southmead, Bristol, UK;(3) National Institute for Medical Research, The Ridgeway, Mill Hill, NW7 1AA London, UK |
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| Abstract: | It has been found that B-cell responses to male-specific antigen(s) can be clearly demonstrated by reversed plaque assays. Female mice injected with syngeneic male spleen cells showed significant increases (greater than 100 × in some strains) in the number of immunoglobulin-secreting cells in lymph nodes draining the injection site. There was a variation in B-cell responsiveness between strains and this correlated only partially with previously reported T-cell responsiveness to the H-Y antigen. C57BL (H-2
b
) mice were among the most responsive, while CBA (H-2
k
), (CBA × C57BL)F1, and BALB/c (H-2
d
) were all much less responsive. These results apparently open up a new approach to the investigation of B-cell responses to male-specific antigen(s). |
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