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Peptide binding motifs and specificities for HLA-DQ molecules
Authors:Andrea Baas  Xiaojiang Gao  G Chelvanayagam
Institution:(1) Human Genetics Group, John Curtin School of Medical Research, Australian National University, Mills Rd, Acton, Canberra, ACT 0200, Australia e-mail Gareth.Chelva@anu.edu.au, Tel.: +61-2-62798247, Fax: 61-2-62494712, AU;(2) Human Genetics Group, John Curtin School of Medical Research, Australian National University, Canberra, ACT 0200, Australia, AU;(3) Laboratory of Genomic Diversity, National Cancer Institute, Frederick, MD 21702, USA, US
Abstract: HLA-DQ molecules have been associated with susceptibility to a number of autoimmune and other diseases, possibly through the peptide repertoire that can be presented by different allelic products. It is thus of importance to understand which peptides can be bound by different HLA-DQ allelic products. Recently, a model for HLA-DQ has been described and used to derive peptide positional environments for HLA-DQ allelic products. By combining the peptide positional environments with known HLA-DQ peptide binding motifs, a set of predictions of likely anchor motifs for many of the products of HLA-DQ allelic variants are made and presented in a table referred to as a roadmap for HLA-DQ peptide binding specificities. Received: 3 March 1999 / Revised: 20 May 1999
Keywords:  HLA-DQ  Peptide binding  Peptide motifs  Autoimmune disease
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