Intra-H-2 recombination in the mouse |
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Authors: | Kirk W Beisel Howard C Passmore Chella S David |
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Institution: | (1) Department of Immunology, Mayo Clinic and Medical School, 55901 Rochester, Minnesota;(2) Department of Zoology, Rutgers University, 08903 New Brunswick, New Jersey;(3) Present address: Department of Immunology and Microbiology, Wayne State University, School of Medicine, 48201 Detroit, Michigan |
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Abstract: | Serological characterization of threeK-S interval recombinant strains, TBR2 (H-2
at2
), TBR3 (H-2
at3
) and AIR1 (H-2
a2
) was performed using anti-H-2, Ia, Ss and Slp antisera. The data presented here reveal that the crossover events in both TBR2 and TBR3 occurred between theI-A andI-E subregions. In both cases, theH-2K andI-A subregions were derived from theH-2
t1
chromosome, while theI-E, S andH-2D regions were derived from theH-2
b
chromosome (K
s
A
k
E
b
S
b
D
b
). TheH-2
a2
chromosome resulted from a crossover event between theH-2
a1
andH-2
i9
chromosomes. Ia and Ss typing of AIR1 suggested that theK toI-E regions originated fromH-2
a1
and theS andD regions originated fromH-2
i9
(K
k
A
k
E
k
S
b
D
d
). |
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Keywords: | |
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