Association of CISH -292A/T genetic variant with hepatitis B virus infection |
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Authors: | Hoang V Tong Nguyen L Toan Le H Song Peter G Kremsner Jürgen F J Kun Velavan TP |
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Institution: | (1) Institute of Tropical Medicine, University of T?bingen, Wilhelmstrasse, 27, 72074 T?bingen, Germany;(2) Department of Pathophysiology, Vietnam Military Medical University, Hanoi, Vietnam;(3) Tran Hung Dao Hospital, Hanoi, Vietnam; |
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Abstract: | Cytokine-inducible SRC homology 2 domain protein (CISH) is a suppressor of cytokine signaling that controls interleukin-2
signaling pathway. We investigated the single nucleotide polymorphism (SNP) -292A>T in 473 Vietnamese hepatitis B virus (HBV)
carriers and 416 healthy controls. CISH variants at -292A>T were associated to HBV infection (Allelic: OR, 1.22 95% CI, 1–1.49; P = 0.04; Recessive: OR, 1.69 95% CI 1.23–2.54; P = 0.007). A gene dose effect for the risk allele -292T was observed (P = 0.04). The level of interleukin 2 and liver enzymes such as alanine transaminase, aspartate transaminase, total bilirubin,
and direct bilirubin were not associated to CISH polymorphism at position -292A>T This study associated the vital role of CISH SNP -292A>T variant to hepatitis B virus infection in a Vietnamese population. |
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