| 整合素在细胞黏附中的生物学功能 |
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| 引用本文： | 刘畅,赵锋,李庆章.整合素在细胞黏附中的生物学功能[J].生物学杂志,2012,29(1):75-78,70. |
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| 作者姓名： | 刘畅 赵锋 李庆章 |
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| 作者单位： | 东北农业大学动物医学学院,哈尔滨,150030 |
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| 基金项目： | 国家重点基础研究发展计划 |
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| 摘 要： | 整合素是一种跨膜蛋白,属于黏附分子家族.其主要功能是参与细胞和细胞、细胞和细胞外基质(ECM)的黏附和信号转导.整合素是含有α和β两条肽链的异源二聚体,来源不同的α、β亚基所形成的整合素具有不同的ECM结合能力.阐述了整合素的结构、生物学功能以及生理、病理学意义,并概述了其研究进展.
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| 关 键 词： | 整合素 细胞外基质 信号转导 细胞骨架 |
Biological function of integrin in cell adhesion |
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| LIU Chang,ZHAO Feng,LI Qing-zhang.Biological function of integrin in cell adhesion[J].Journal of Biology,2012,29(1):75-78,70. |
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| Authors: | LIU Chang ZHAO Feng LI Qing-zhang |
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| Institution: | 3(College of Animal Medicine,Northeast Agricultural University,Harbin 150030,China) |
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| Abstract: | Integrin is a transmembrane protein,belonging to the adhesion molecule family.The major function of integrin is participating cell to cell and cell to extracellular matrix（ECM） adhesion and signal transduction.Integrin is a dimeric complex with two heterologous subunits α and β polypeptide.Integrin dimmers with different α and β variants have different binding abilities to ECM.In this mini-review,advance in the structural and functional study of integrin was summarized and its significance in pathology and physiology was discussed. |
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| Keywords: | integrin extracellular matrix signal transduction cystoskeleton |
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