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| 肌球蛋白Ⅵ定向运动的蒙特卡罗模拟 | |
| 引用本文： | 李晨璞,支雄莉,韩英荣.肌球蛋白Ⅵ定向运动的蒙特卡罗模拟[J].生物学杂志,2010,27(3):8-12. |
| 作者姓名： | 李晨璞 支雄莉 韩英荣 |
| 作者单位： | 1. 河北建筑工程学院,张家口,075024 2. 张家口市第一医院,张家口,075000 3. 河北工业大学理学院,天津,300401 |
| 摘 要： | 根据myosin Ⅵ分子马达头部核苷的变化建立一个四态循环,然后利用蒙特卡罗方法模拟分子马达的动力学性质,讨论了myosin Ⅵ速度、滞留时间与溶液中ATP浓度、ADP浓度和负载力F的关系。模拟得到：myosin Ⅵ会在轨道微丝上进行梯跳运动并且每次在微丝上的滞留时间并不相同;另外,myosin Ⅵ的速度会随着ATP浓度的增加而增大,随着ADP浓度和负载力的增加而减小;负载力对myosin Ⅵ在胞内执行输运还是连接功能起一定的调节作用。 |
| 关 键 词： | 分子马达 肌球蛋白 蒙特卡罗模拟 反应速率 |
Monte carlo simulation of the directional motion of myosin VI |
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| LI Chen-pu,ZHI Xiong-li,HAN Ying-rong.Monte carlo simulation of the directional motion of myosin VI[J].Journal of Biology,2010,27(3):8-12. | |
| Authors: | LI Chen-pu ZHI Xiong-li HAN Ying-rong |
| Institution: | 1.Hebei Institute of Architecture Civil Engineering,Zhangjiakou 075024;2.First Hospital of Zhangjiakou,Zhangjiakou 075000; 3.Institute of Biophysics,HeBei University of Technology,Tianjin 300401,China) |
| Abstract: | According to the transformation of nucleotide in the motor domain of myosin Ⅵ,a circular model of four states as former some models was found.By using Monte Carlo method to simulate the dynamic characters basing on chemical reaction rates between two states,the relations among the displacement,the velocity,the dwell time of myosin Ⅵ with concentration of ATP,ADP and backward load F were analyzed.The dwell time of myosin Ⅵ during every cycle is different.The velocity of myosin Ⅵ would be faster when concentration of ATP increased,and slower when concentration of ADP increased.Otherwise backward load F might play an adjustive function between translocation and anchoring in cell. |
| Keywords: | motor molecular myosin Monte Carlo reaction rates |
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