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铅对小鼠血液和肝肾影响的实验性初步观察
引用本文:赵剑,童希琼,蔡亚非.铅对小鼠血液和肝肾影响的实验性初步观察[J].生物学杂志,2010,27(1):17-19,38.
作者姓名:赵剑  童希琼  蔡亚非
作者单位:1. 安徽师范大学生命科学学院安徽省资源保护与利用重点实验室生物环境与生态安全安徽省高校重点实验室
2. 安徽师范大学校医院,芜湖,241000
基金项目:科技部"十一五"国家科技支撑计划,安徽省自然科学基金,芜湖市科技计划重点项目 
摘    要:用全血细胞分析仪检测染毒小鼠新鲜血样,再用日立7020生化分析仪,配合试剂盒法对血清进行检测,研究铅对血液与肝肾功能的影响,结果表明:100mg/kg浓度的醋酸铅对小鼠的血液有显著影响,白细胞数目(WBC),淋巴细胞数目(Lymph),中性粒细胞数目(Gran)等指标显著增加(P〈0.05),此外对血小板凝血系统功能显著影响,血小板数目(PLT)等指标下降极显著(P〈0.01),对血红细胞(RBC),血红蛋白(HGB)等指标影响不显著(P〉0.05)。肝肾功能性指标:谷丙转氨酶(AIJT),谷草转氨酶(AST)尿素氮(UREA)肌酐(CREA)生化酶显著偏离正常值(P〈0.05)。表明铅对肝脏肾脏功能有显著的破坏。对检测结果做了进一步的分析讨论。

关 键 词:醋酸铅  全血参数  尿素氮  谷丙转氨酶

The preliminary researches on the toxic effects of Pb on mouse blood,liver and kidney
ZHAO Jian,TONG Xi-qiong,CAI Ya-fei.The preliminary researches on the toxic effects of Pb on mouse blood,liver and kidney[J].Journal of Biology,2010,27(1):17-19,38.
Authors:ZHAO Jian  TONG Xi-qiong  CAI Ya-fei
Institution:ZHAO Jian1,TONG Xi-qiong2,CAI Ya-fei 1(1.College of Life Science,Anhui Normal University,The Key Laboratory of Bioresource Protection , utilization of Anhui province The Key laboratory of Biotic Environment , Ecological Safety in Anhui Province,2.University Hospital of Anhui Normal University,Wuhu 241000,China)
Abstract:The automatic blood cell analyzer was used to assay the blood indexes of the mice induced by acute Pb toxicosis,and then Hitachi 7020 biochemical analyzer was used to check the serum indexes of the function of the liver and kidney.The results showed as follows:100mg/kg Pb impacted on the blood of mice immune system and significantly impacted on the number of cells like white blood(WBC),lymphocytes(Lymph),neutrophils(Gran) with significantly increased indexes(P <0.05).It had impacted on the platelet clotting...
Keywords:lead acetate  blood parameters  usea nitrogen  glutamic-pyruvic transaminase
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