日本血吸虫GST蛋白和14-3-3蛋白的研究进展

血吸虫病是严重危害人类健康的人兽共患病之一,在全球范围内,血吸虫病曾在76个国家和地区流行,有超过2亿人感染了血吸虫病。目前,世界上采取了一些人畜同步治疗等综合防治措施,虽取得了一定的成效,但仍面临着成本高、再感染率高等一系列问题。因此,寻找新的治疗药物、疫苗候选分子以及开发高度特异且敏感的标准化免疫诊断试剂是当前日本血吸虫病基础研究的重要内容。主要对WHO提出的最具潜力的疫苗候选分子血吸虫GST蛋白以及参与血吸虫许多生物学功能的14-3-3蛋白的最新研究进展进行一些阐述。

Advances in Schistosoma japonicum recombinant protein glutathione-S-transferase(SjGST)and Schistosoma japonicum signaling protein 14-3-3(Sj14-3-3)

Schistosomiasis is one of the serious health-threatening parasitic zoonoses to human beings. It has been presented in 76 countries and regions. More than 200 million people have been suffered from the infectious diseases all over the world. At present, some comprehensive precautionary and therapeutic measures were introduced to prevent schistosomiasis of human beings and animals simultaneously. The measures have brought some obvious positive effects, but the high cost combined with the high re-infection rate and such problems are still barriers to the application of the measures. Thus, to seek novel therapeutic medicines, candidates for the vaccines and also manage to develop standard immunologic diagnosis reagents with high specificity and sensitivity is the essential topic of the basic schistosomiasis research currently. The recent study of progress of the SjGST protein was reviewed, most potential candidates for the vaccines presented by WHO were summarized. Besides, this paper briefly reviewed the Sj14-3-3 protein which was involved in many functions of Schistosoma.