| 重庆居民5-HT2A基因多态性与原发性高血压关系 |
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| 引用本文： | 窦贵旺,綦岩,吴志红.重庆居民5-HT2A基因多态性与原发性高血压关系[J].生物学杂志,2011,28(3):5-7,11. |
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| 作者姓名： | 窦贵旺 綦岩 吴志红 |
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| 作者单位： | 1. 重庆医科大学公共卫生学院,重庆,400016
2. 内蒙古呼和浩特炼油厂生活区职工医院,呼和浩特,010070 |
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| 基金项目： | 重庆市科委自然科学基金 |
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| 摘 要： | 以聚合酶链PCR法分析重庆市一般人群的5-HT2A基因C102T多态性(样本总数348人,其中高血压组:HT=137例,非高血压组:NT=211例)的临床指标间的相关性与频率分布。了解重庆地区汉族人群5-羟色胺受体2基因(5-hydroxytryptamine receptor gene,5-HT2A)C102T多态性与原发性高血压病(essential hypertension,EH)的关系。卡方检验结果显示5-HT2A的C102T基因多态性(P=0.549)与等位基因频率(P=0.263)在HT与NT之间没有显著性统计学差异;5-HT2A的C102T基因多态性与高血压logistic回归模型分析结果显示也未见显著性差异,卡方值(Wald)为0.399;比值比为0.884;95%的可信区间为0.603~1.296,P值为0.528。一般线性模型分析结果:5-HT2A基因C102T多态性与收缩压,舒张压之间没有显著性统计学差异,PSBP=0.868,PDBP=709。5-HT2A的C102T多态性可能与重庆汉族人群EH无关。
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| 关 键 词： | 原发性高血压 5-羟色胺受体2基因 基因多态性 |
The association between 5-HT2A gene polymorphism and hypertension in Chongqing |
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| DOU Gui-wang,QI Yan,WU Zhi-hong.The association between 5-HT2A gene polymorphism and hypertension in Chongqing[J].Journal of Biology,2011,28(3):5-7,11. |
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| Authors: | DOU Gui-wang QI Yan WU Zhi-hong |
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| Institution: | DOU Gui-wang 1,QI Yan 2,WU Zhi-hong 1(1.Department of Public Health,Chongqing Medical University,Chongqing 400016,2.Living Quarter Staff-Worker Hospital in Huhehaote Petroleum Refinery,Huhehaote 010070,China) |
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| Abstract: | To investigate the association between C102T polymorphisms in 5-hydroxytryptamine receptor gene and essential hypertension(EH) in Chongqing population,a case-control study consisted of 211 essential hypertensive subjects(HT) and 137 normotensive controls(NT) was performed.The 5-HT2A C102T polymorphisms were determined in DNA extracted from peripheral blood leukocytes by a polymerase chain reaction(PCR)-RLFP.The chi-square analysis results showed the data had no significant statistics differences in both gen... |
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| Keywords: | essential hypertension 5-hydroxytryptamine receptor gene polymorphism |
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