| N-甲基-D-天氡氨酸受体的分子结构与生理功能 |
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| 引用本文： | 林奕斌,赵同军,展永.N-甲基-D-天氡氨酸受体的分子结构与生理功能[J].生物学杂志,2007,24(1):1-4. |
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| 作者姓名： | 林奕斌 赵同军 展永 |
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| 作者单位： | 1. 河北工业大学生物物理研究所,天津,300130;中国科学院上海生命科学研究院,上海,200031
2. 河北工业大学生物物理研究所,天津,300130 |
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| 基金项目： | 国家自然科学基金;河北省自然科学基金 |
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| 摘 要： | NMDA(N-甲基-D-天氡氨酸)受体是离子型谷氨酸受体的一种亚型,在中枢神经系统的突触传递和突触可塑性调节中起着重要的作用。生物体内已经发现了三种NMDA受体亚基,通过基因的选择性剪切可产生多种亚单位。NMDA受体是一个具有多个结合位点的大分子复合物,其生理特性同异聚体通道的装配密切相关。NMDA受体的异常会导致一些认知功能的缺失,这为治疗性药物开发提供了靶点。
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| 关 键 词： | NMDA受体 阿尔茨海默病 |
| 文章编号： | 1008-9632（2007）01-0001-04 |
| 修稿时间： | 2006-02-17 |
Molecular structure and physiological function of N-methyl-D-aspartic acid receptor |
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| LIN Yi-bin,ZHAO Tong-jun,ZHAN Yong.Molecular structure and physiological function of N-methyl-D-aspartic acid receptor[J].Journal of Biology,2007,24(1):1-4. |
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| Authors: | LIN Yi-bin ZHAO Tong-jun ZHAN Yong |
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| Institution: | 1. Institute of Biophysics, Hebei University of Technology, Tianjin 300130, China; 2. Shanghai Institute for Biological Science, Chinese Aeademg of Sciences, Shanghai 200031, China |
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| Abstract: | Glutamate receptors of the N-methyl-D-aspartate(NMDA) subtype are highly expressed in the central nervous system and are involved in excitatory synaptic transmission and synaptic plasticity.Prolonged activation of NMDA receptors can lead to excitotoxicity.There are three kinds of subunit of NMDA acceptor discoverd in life body.These receptors are heteromeric ion channels and their activation requires binding of glycine and glutamate to the NR1 and NR2 subunits,respectively.NMDA receptors possess several binding sites that, when activated by the appropriate pharmacological substances,can influence on the receptors' function.Pathological changes will lead to lose some cognitive functions that gives the target for the developing of medicine. |
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| Keywords: | NRl NR2 |
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