| 幼年和老年大鼠学习中海马CA_3区长时程突触增强的年龄特征 |
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| 引用本文： | 李君,许世彤,区英琦.幼年和老年大鼠学习中海马CA_3区长时程突触增强的年龄特征[J].动物学研究,1991(3). |
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| 作者姓名： | 李君 许世彤 区英琦 |
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| 作者单位： | 华南师范大学 广州
(李君，许世彤)，华南师范大学 广州(区英琦) |
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| 摘 要： | 研究发现幼年和老年大鼠在条件性饮水反应的建立、消退和再建立过程中,海马CA_3区有习得性长时程突触增强(LTP)的形成、消退和再形成现象。在它的形成和再形成以及每实验日训练作业后习得性LTP的发展上,幼年鼠明显快于老年鼠,而习得性LTP的消退,在两组间无明显差异。这既表明海马CA_3区的习得性LTP具年龄特征,也为论证习得性LTP可能是学习和记忆的神经基础之一提供了新的证据。
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| 关 键 词： | 海马CA_3区 长时程突触增强 学习 记忆 年龄特征 |
THE AGE CHARACTERISTICS OF THE LONG-TERM SYNAPTIC POTENTIATION IN THE CA3 REGION OF HIPPOCAMPUS OF THE YOUNG AND THE AGED RATS DURING THE LEARNING |
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| Li Jun Xu shiting Qu Yingqi.THE AGE CHARACTERISTICS OF THE LONG-TERM SYNAPTIC POTENTIATION IN THE CA3 REGION OF HIPPOCAMPUS OF THE YOUNG AND THE AGED RATS DURING THE LEARNING[J].Zoological Research,1991(3). |
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| Authors: | Li Jun Xu shiting Qu Yingqi |
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| Abstract: | The learning-dependent long-term potentiation (LTP) in the hippocampal CA3 region of the young and aged rats all was changed obviously during the establishment, extinction and re-establishment of conditioned drink response. The velocity of establishment and development of the learning-dependent LTP in CA3 of the young rats is more than that of the aged rats. However there was nonsignificant difference in the extinction of the learning-dependent LTP in CA3 of the young and the aged rats. These results not only showed that there was the age characteristics of the learning-dependent LTP in the CA3 region but also provided a evidence that the learning-dependent LTP might be one of the neural bases of learning and memory. |
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| Keywords: | Hippocampal CA_3 region Long-term potcntiation of the synaptic efficacy Learning Memory Age characteristics |
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