长期注射吗啡对戒断后小鼠Y－迷宫空间识别记忆的影响

使用急性成瘾性药物会影响大脑功能，随着药物使用时间的延长，这种影响更加广泛、持久，并且在药物戒断后的很长时间内依然存在。实验表明，急性及短期吗啡给予小鼠和戒断均损伤了其Y迷宫空间识别记忆能力，但这种损伤短暂且可逆。本实验小鼠被连续注射吗啡（40 mg/kg•day，i p）或生理盐水21天，利用Y迷宫来检测长期吗啡给予后在戒断第2、9和19天，吗啡对小鼠空间识别记忆的影响。结果表明, 连续吗啡给予21天后，在戒断第2、9和19天，小鼠Y迷宫空识别记忆能力均受到损伤，提示长期给予小鼠吗啡会导致其空间识别记忆能力的长期损伤。

Effects of Withdrawal on Y-maze Spatial Recognition Memory in Mice after Long-term Morphine Injection

Acute drug use modifies brain function in critical ways, and prolonged drug use causes pervasive changes in brain function that persist long after withdrawal. Our previous studies proved that acute or four-day morphine injection impaired mice spatial recognition memory in the Y-maze, but the impairment was short and reversible. In the present study, morphine or saline (40 mg/ kg·day, ip) was injected into mice for 21 days. Spatial recognition memory was tested in the Y-maze on the 2nd, 9th and 19th withdrawal day. Our results showed that spatial recognition memory of morphine-injected mice was impaired on each of the three test days. Our study clearly suggests that long-term morphine use leads to more persistent impairments of spatial recognition memory.