频繁使用染发剂对小鼠染色体畸变率影响的研究

研究了多次接触７ 种染发剂对不同组小鼠骨髓和生殖细胞染色体畸变率的影响。结果发现， ７ 种染发剂均导致出现较高的染色体畸变率，３ 种能引起小鼠骨髓细胞染色体畸变率显著上升， 其中以粉末状染发剂的影响最为严重。４ 种染发剂对进行生殖细胞染色体畸变实验的小鼠均产生显著影响， 尤以氧化型染发剂最为明显。

STUDY ON CHROMOSOMAL ABERRATION OF MOUSE BONE MARROW CELLS AND GERMINAL CELLS INDUCED BY HAIR DYES

Seven kinds of hair dye are selected to lay on the skins of NIH strain mouse.After being touched with the hair dyes 7 times during 23 days,the mouse bone marrow cells and testis cells are collected to observe the chromosomal aberrations.The results show that all kinds of hair dye can induce the chromosomal aberration of mouse bone marrow cells and the aberration types include break,fragment,ring and so on.The ratios of chromosomal aberrations induced by three kinds of hair dye are statistically significant higher than control and the powdery types are the highest.Four kinds of hair dye of the seven have been to studied the chromosomal aberrations of the male mouse germinal cells.All of them induce the chromosomal aberration of the germinal cells (the aberration types include fragment,monovalent,quadrivalent),and the aberration ratios are statistically significant higher and the instant oxidative types are the highest.