Timeless与生物钟基因

综述了timeless基因的发现、多态性和重要功能。timeless是最先被发现的两个生物钟基因之一。生物钟的昼夜节律由PER、TIM、CLOCK和CYCLE4个生物钟齿轮组成的正负反馈回路进行调节。其中TIM可以受光因子调控，它还可以与PER形成异二聚体，通过正负调控方式调节果蝇的昼夜节律行为。

Timeless Gene and Biological Clock Genes

The article summarized the discovery,polymorphyism and important function of the timeless gene.It is one of the two firstly discoverd biological clock genes.The circadian rhythms are controlled through autoregulatory feedback loop by the products of the biological clock genes including PER,TIM,CLOCK and CYCLES.The TIM may be regulated by light and form a allodimmer with PER,and the allodimmer can drive the circadian behavioral processes of Drosophila .The lucubrating of the mechanism of biological clock genes will greatly be helpful to explain the human complex behaviors.