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| 树鼩神经肽Y的分子克隆及其灵长类类似物的同源性比较 | |
| 作者姓名： | Dong L Lv LB Lai R |
| 作者单位： | 1. 中国科学院和云南省动物模型与人类疾病机理重点实验室, 中国科学院昆明动物研究所, 云南 昆明 650223; 2. 中国科学院研究生院, 北京 100049 |
| 基金项目： | 中国科学院基础前沿研究专项项目(KSCX2-EW-R-11, KSCX2-EW-J-23); 中国科学院和云南省动物模型与人类疾病机理重点实验室资助项目 |
| 摘 要： | 树鼩由于与灵长类动物有较密切的亲缘关系和其个体小,以及繁殖周期短等特性而倍受关注,尤其是作为医用实验动物的研究,近年来已受到越来越多的重视,但树鼩的分类地位还一直有所争论。该研究从树鼩脑cDNA文库中克隆得到编码树鼩神经肽Y(neuropeptide Y,NPY)前体序列,序列比对发现该序列与灵长类NPY序列同源性高达96.9%。将该序列与GenBank数据库中其他物种的NPY序列构建系统进化树,发现树鼩与灵长类处于同一分支。该研究结果揭示了树鼩与灵长类较近的亲缘关系。 |
| 关 键 词： | 神经肽Y 树鼩 灵长类 |
| 收稿时间： | 2011-10-31 |
| 修稿时间： | 2011-12-29 |
Molecular cloning of Tupaia belangeri chinensis neuropeptide Y and homology comparison with other analogues from primates |
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| Dong L,Lv LB,Lai R.Molecular cloning of Tupaia belangeri chinensis neuropeptide Y and homology comparison with other analogues from primates[J].Zoological Research,2012,33(1):75-78. | |
| Authors: | Dong Li Lv Long-Bao Lai Ren |
| Institution: | 1. Key Laboratory of Animal Models and Human Diseases Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming 650223, China; 2. Graduate University of the Chinese Academy Sciences, Beijing 100049, China |
| Abstract: | Much attention has been payed to tree shrews for their close phylogenetic relationship with primates, small size, and short reproductive cycle. Especially, they are considered as excellent experiential animals for medicine or/and disease research. A nucleotide sequence encoding neuropeptide Y(NPY) precursor has been cloned from the cDNA library of Tupaia belangeri chinensis. Sequence alignment revealed that the sequence homology with primate NPY was up to 96.9%. The phylogenetic analysis based on NPY precursor sequence revealed that the tree shrew has a close relationship with primates. |
| Keywords: | Neuropeptide Y " target="_blank">Tupaia belangeri chinensiszz')" href="#"> Tupaia belangeri chinensis Primates |
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