首页 | 本学科首页   官方微博 | 高级检索  
   检索      

HIV-1的表型及其感染的细胞嗜性
引用本文:张驰宇.HIV-1的表型及其感染的细胞嗜性[J].动物学研究,2004,25(4):363-368.
作者姓名:张驰宇
作者单位:江苏大学,医学技术学院,江苏,镇江,212001
基金项目:江苏大学高级技术人才科研启动基金资助项目 ( 2 2 812 70 0 0 2 )
摘    要:HIV-1的表型分为合胞体诱导型(syncytium-inducing,SI)和非合胞体诱导型(non-syncytium-inducing,NSI)。依据所用辅助受体和感染靶细胞的不同,HIV-1又被分为R5、X4和R5X4型。R5和X4型病毒分别利用CCR5和CXCR4作为辅助受体,而R5X4型病毒可利用这两种辅助受体。在病毒的复制力、细胞嗜性以及合胞体诱导能力上,SI型与X4型病毒一致,NSI型与R5型病毒一致。在HIV-1感染过程中,疾病的发展伴随着病毒从NSI型向SI型、及R5型向X4型的转变。HIV-1的表型影响和决定着HIV-1的感染、传播及AIDS的疾病进程。HIV-1的表型和细胞嗜性主要由病毒gp120的V3区(特别是第11和25位的氨基酸)决定。V3区的氨基酸序列信息,将为预测HIV-1的表型,以及病毒感染后的疾病进程提供生物信息学的依据。

关 键 词:HIV-1  表型  感染  细胞嗜性  辅助受体  人免疫缺陷病毒1型  艾滋病
文章编号:0254-5853(2004)04-0363-06

Phenotype and Cellular Tropism of Human Immunodeficiency Virus Type 1
ZHANG Chi-yu.Phenotype and Cellular Tropism of Human Immunodeficiency Virus Type 1[J].Zoological Research,2004,25(4):363-368.
Authors:ZHANG Chi-yu
Institution:School of Medical Technology,Jiangsu University,Zhenjiang,Jiangsu 212001,China
Abstract:Human immunodeficiency virus type 1 (HIV-1) isolates are classified phenotyically into syncytium-inducing (SI) and non-syncytium-inducing (NSI) according to their capacity to induce syncytia in MT-2 cells.Strains of HIV-1 are also classified based on their co-receptor usage.Viruses using the seven-transmembrane,G-protein-coupled,chemokine receptor CCR5,CXCR4,or both are termed R5,X4,and R5X4,respectively.HIV-1 strains of SI and X4 appear to have identical biological properties such as replication rate,cell tropism,and syncytium-inducing capacity.NSI and R5 viruses also show identical biological properties.The phenotypes of HIV-1 influence and determine viral transmission,pathogenesis and disease progression.In the course of HIV-1 infection,disease progression is associated with a switch in viral phenotype from NSI to SI,and a change in co-receptor usage from CCR5 to CXCR4.The V3 domain of HIV-1 gpl20,specifically,amino acids at V3 position 11 and 25,play a dominant role in determinant of viral phenotype and co-receptor usage.V3 sequences provide important information for prediction of HIV-1 phenotype and disease progression using bioinformatics approaches.
Keywords:HIV-1  V3 domain  SI/NSI  Cellular tropism  Co-receptor  
本文献已被 CNKI 维普 万方数据 等数据库收录!
点击此处可从《动物学研究》浏览原始摘要信息
点击此处可从《动物学研究》下载免费的PDF全文
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号