| MicroRNAs与多潜能干细胞的研究进展 |
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| 引用本文： | 王彩云,杨世华.MicroRNAs与多潜能干细胞的研究进展[J].动物学研究,2012,33(4):416-420. |
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| 作者姓名： | 王彩云 杨世华 |
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| 作者单位： | 昆明理工大学生命科学与技术学院,云南昆明,650500 |
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| 基金项目： | 国家自然科学基金，云南省科技创新人才计划项目 |
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| 摘 要： | microRNAs(miRNAs)是一类内源性非编码小RNA,通过调控基因表达来参与生命过程中的一系列重要进程。越来越多的证据表明,miRNAs参与了几乎所有生物代谢过程,其胚胎干细胞的自我更新与分化和在多能干细胞(iPSCs)中的诱导调节作用也日益受到关注。该文介绍了miRNAs的生成、检测方法以及miRNAs对胚胎干细胞(ESCs)及诱导多能性干细胞的调控作用,并对miRNAs的应用前景进行了展望。
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| 关 键 词： | miRNAs miRNAs检测 胚胎干细胞 诱导多能性干细胞 |
Research on MicroRNAs in pluripotent stem cells |
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| WANG Cai-Yun
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YANG Shi-Hua.Research on MicroRNAs in pluripotent stem cells[J].Zoological Research,2012,33(4):416-420. |
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| Authors: | WANG Cai-Yun YANG Shi-Hua |
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| Institution: | Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China. yangsh@kmust.edu.cn. |
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| Abstract: | MicroRNAs (miRNAs) are a newly identified class of small regulatory non-coding endogenous RNAs that take part in a series of important processes by regulating gene expression. Recent studies have provided evidence that miRNAs may be involved in nearly all biological and metabolic processes, especially influencing self-renewal and differentiation of embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). In this review, we briefly summarize the biological characteristics of miRNAs, the detection technologies, and the role of miRNAs regulation in ESCs and iPSCs to frame a discussion on the future prospects of miRNA research. |
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