Novel cell surface genes expressed in the stomach primordium during gastrointestinal morphogenesis of mouse embryos |
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| Authors: | Taka-aki K Noguchi Hisako Ishimine Yoshiro Nakajima Kanako Watanabe-Susaki Naoki Shigeta Norio Yamakawa Pi-Chao Wang Makoto Asashima Akira Kurisaki |
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| Institution: | 1. Graduate School of Life and Environmental Sciences, The University of Tsukuba, Japan;2. Research Center for Stem Cell Engineering, National Institute of Advanced Industrial Science and Technology (AIST), Japan;3. Life Science Center of Tsukuba Advanced Research Alliance, The University of Tsukuba, Japan;4. Department of Life Sciences (Biology), Graduate School of Arts and Sciences, The University of Tokyo, Japan |
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| Abstract: | The mechanisms of gastrointestinal morphogenesis in mammals are not well understood. This is partly due to the lack of appropriate markers that are expressed with spatiotemporal specificity in the gastrointestinal tract during development. Using mouse embryos, we surveyed markers of the prospective stomach region during gastrointestinal morphogenesis. The initiation of organ bud formation occurs at E10.5 in mice. These primordia for the digestive organs protrude from a tube-like structured endoderm and have their own distinct morphogenesis. We identified 3 cell surface genes – Adra2a, Fzd5, and Trpv6 – that are expressed in the developing stomach region during gastrointestinal morphogenesis using a microarray-based screening. These novel genes will be useful in expanding our understanding of the mechanisms of gastrointestinal development. |
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