Estimation of the number of nucleotide substitutions in the control region of mitochondrial DNA in humans and chimpanzees |
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Authors: | Tamura K; Nei M |
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Institution: | Department of Biology, Pennsylvania State University. |
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Abstract: | Examining the pattern of nucleotide substitution for the control region of
mitochondrial DNA (mtDNA) in humans and chimpanzees, we developed a new
mathematical method for estimating the number of transitional and
transversional substitutions per site, as well as the total number of
nucleotide substitutions. In this method, excess transitions, unequal
nucleotide frequencies, and variation of substitution rate among different
sites are all taken into account. Application of this method to human and
chimpanzee data suggested that the transition/transversion ratio for the
entire control region was approximately 15 and nearly the same for the two
species. The 95% confidence interval of the age of the common ancestral
mtDNA was estimated to be 80,000-480,000 years in humans and 0.57-2.72 Myr
in common chimpanzees.
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